Stress hormones can prevent disorders after a traumatic event
Thursday, September 14, 2017 IST
In a recent study, a group of researchers have found that the Ppm1f (Protein phosphatase 1f) gene is altered when exposed to traumatic stress and is associated with posttraumatic stress disorder, depression and anxiety. People who have suffered from traffic accidents, war combat, terrorist attacks and exposure to other traumatic events have an increased likelihood of developing diseases.
These diseases can be psychological and physical, such as heart problems and cancer. The current preventive treatments based on psychological support and drugs are effective in some cases. Unfortunately, these treatments do not work for many individuals. It is also known that the earlier the treatment starts, the better to prevent future negative consequences.
Scientists have discovered in a study with mice and humans that the Ppm1f gene expression is one of the most highly regulated after exposure to traumatic stress. Ppm1f is associated with posttraumatic stress disorder (PTSD), depression and anxiety. The main function of Ppm1f is to regulate the activity of the protein Camk2 (Calmodulin-dependent protein kinase 2), which is key in many processes of the human body such as memory, the heart’s functioning and the immune system.
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