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Alzheimer’s, Parkinson’s disease can be prevented with the help of this gene
Wednesday, July 18, 2018 IST
Alzheimer’s, Parkinson’s disease can be prevented with the help of this gene

Researchers found that the Ankrd16 gene rescued specific neurons, which in turn help in the prevention of diseases such as Alzheimer’s and Parkinson’s.

 
 

Alzheimer’s and Parkinson’s disease can be prevented by the Ankrd16 gene, a new study has shown. The gene can prevent faulty proteins from causing neurological disorders.
 
In a recent study, researchers found out about this gene. Scientists know that faulty proteins can cause harmful deposits or “aggregates” in neurological disorders such as Alzheimer’s and Parkinson’s disease. Although the causes of these protein deposits remain a mystery, it is known that abnormal aggregates can result when cells fail to transmit proper genetic information to proteins.
 
Usually, the information transfer from gene to protein is carefully controlled--biologically “proofread” and corrected-to avoid the production of improper proteins. Researchers found that the Ankrd16 gene rescued specific neurons-called Purkinje cells -that die when proofreading fails.
 
Without normal levels of Ankrd16, these nerve cells, located in the cerebellum, incorrectly activate the amino acid serine, which is then improperly incorporated into proteins and causes protein aggregation.
 
“Simplified, you may think of Ankrd16 as acting like a sponge or a ‘failsafe’ that captures incorrectly activated serine and prevents this amino acid from being improperly incorporated into proteins, which is particularly helpful when the ability of nerve cells to proofread and correct mistakes declines,” said a researcher, Ackerman.
 
The levels of Ankrd16 are normally low in Purkinje cells, making these neurons vulnerable to proofreading defects. Elevating the level of Ankrd16 protects these cells from dying, while removing Ankrd16 from other neurons in mice with a proofreading deficiency caused widespread buildup of abnormal proteins and ultimately neuronal death.
 
 

 
 

The researchers describe Ankrd16 as a new layer of machinery essential for preventing severe pathologies that arise from defects in proofreading.
 
The researchers noted that only a few modifier genes of disease mutations such as Ankrd16 have been identified and a modifier-based mechanism for understanding the underlying pathology of neurodegenerative diseases might be a promising route to understand them.
 
The study appeared in the Nature Journal.

 
 
 
 
 

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एक दीप तुम प्यार का, रखना दिल के द्वार, यही दीप का अर्थ है, यही पर्व का सार. दीप हृदय में कर गये, खुशियों का बौछार, आज प्रेम से हम करें, दीपों का सत्कार. केसर, चन्दन घर लगे, रोली अक्षत द्वार, सजी दीप की अल्पना, किरणें वन्दनवार. फूल -पंखुड़ी तन हुआ, हृदय हुआ अब दूब, दीप -पर्व के ताल में, हम सब जायें ड़ूब. दीप -पर्व सी ज़िन्दगी, दीप तुम्हारा प्यार, तुम रंगोली अल्पना, तुम ही वन्दनवार. दिया एक विश्वास का, जले हृदय में आज, सद्भाव को नोच रहे, आजा घृणा के बाज़. उड़ी गगन में प्रेम की, किरणें पंख पसार, हुआ पराजित दीप से, फिर तिमिर एक बार.
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Shibu Chandran
2 hours ago

Serving political interests in another person's illness is the lowest form of human value. A 70+ y old lady has cancer.

November 28, 2016 05:00 IST
Shibu Chandran
2 hours ago

Serving political interests in another person's illness is the lowest form of human value. A 70+ y old lady has cancer.

November 28, 2016 05:00 IST
Shibu Chandran
2 hours ago

Serving political interests in another person's illness is the lowest form of human value. A 70+ y old lady has cancer.

November 28, 2016 05:00 IST
Shibu Chandran
2 hours ago

Serving political interests in another person's illness is the lowest form of human value. A 70+ y old lady has cancer.

November 28, 2016 05:00 IST


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