Alzheimer’s, Parkinson’s disease can be prevented with the help of this gene
Food & Health  
Hindustan Times

Researchers found that the Ankrd16 gene rescued specific neurons, which in turn help in the prevention of diseases such as Alzheimer’s and Parkinson’s.

 

Alzheimer’s and Parkinson’s disease can be prevented by the Ankrd16 gene, a new study has shown. The gene can prevent faulty proteins from causing neurological disorders.
 
In a recent study, researchers found out about this gene. Scientists know that faulty proteins can cause harmful deposits or “aggregates” in neurological disorders such as Alzheimer’s and Parkinson’s disease. Although the causes of these protein deposits remain a mystery, it is known that abnormal aggregates can result when cells fail to transmit proper genetic information to proteins.
 
Usually, the information transfer from gene to protein is carefully controlled--biologically “proofread” and corrected-to avoid the production of improper proteins. Researchers found that the Ankrd16 gene rescued specific neurons-called Purkinje cells -that die when proofreading fails.
 
Without normal levels of Ankrd16, these nerve cells, located in the cerebellum, incorrectly activate the amino acid serine, which is then improperly incorporated into proteins and causes protein aggregation.
 
“Simplified, you may think of Ankrd16 as acting like a sponge or a ‘failsafe’ that captures incorrectly activated serine and prevents this amino acid from being improperly incorporated into proteins, which is particularly helpful when the ability of nerve cells to proofread and correct mistakes declines,” said a researcher, Ackerman.
 
The levels of Ankrd16 are normally low in Purkinje cells, making these neurons vulnerable to proofreading defects. Elevating the level of Ankrd16 protects these cells from dying, while removing Ankrd16 from other neurons in mice with a proofreading deficiency caused widespread buildup of abnormal proteins and ultimately neuronal death.
 
 

 

The researchers describe Ankrd16 as a new layer of machinery essential for preventing severe pathologies that arise from defects in proofreading.
 
The researchers noted that only a few modifier genes of disease mutations such as Ankrd16 have been identified and a modifier-based mechanism for understanding the underlying pathology of neurodegenerative diseases might be a promising route to understand them.
 
The study appeared in the Nature Journal.

 
 


 
 


 
More in Food & Health
Burn Bay Leaves In Your Home For These Health Benefits

The bay leaf, also known under its scientific name, Laurus nobilis, is a leaf from the bay laurel tree.

Recently posted . 5 views

Eggs for breakfast benefit those with Type 2 diabetes

According to the findings, a high-fat, low-carb breakfast (LCBF) can help those with T2D control blood sugar levels throughout the day.  

Recently posted . 14 views

Safe Workout, Fitness Tips for Pregnant Women

Scroll downs to find new tips for a safe workout and fitness during pregnancy.   One of the biggest stereotypes in our society ...

Recently posted . 20 views

10 Ways to Clean Yellow Teeth Naturally

Whether its intrinsic or extrinsic stains, tooth discoloration can cause a tremendous sense of insecurity of most people. That said, tooth discoloration can be a by...

1 week ago . 41 views

12 Easy Ways to Treat Swollen Gums Naturally

In medical terminology, swollen gums are known as gingival swelling or gingivitis. Many reasons can cause your gums to swell. Some of these causes include pregnancy...

1 week ago . 41 views

 
 
 

Prashnavali

Thought of the day

"I have not failed. I've just found 10,000 ways that won't work."
Thomas A. Edison