Blood cancer can accelerate ageing in healthy bone marrow cells, scientists have found for the first time, paving the way for anti-ageing drugs in the future.
It is well known that ageing promotes cancer development. However, this is the first time that the reverse has been shown to be true, according to researchers from the University of East Anglia (UEA) in the UK.
The study, published in the journal Blood, shows that healthy bone marrow cells were prematurely aged by cancer cells around them.
The aged bone marrow cells accelerated the growth and development of the leukaemia -- creating a vicious cycle that fuels the disease.
The study also identified the mechanism by which this process of premature ageing occurs in the bone marrow of leukaemia patients and highlights the potential impact this could have on future treatments.
"Our results provide evidence that cancer causes ageing. We have clearly shown that the cancer cell itself drives the ageing process in the neighbouring non-cancer cells," said Stuart Rushworth from UEA.
"Our research reveals that leukaemia uses this biological phenomenon to its advantage to accelerate the disease," said Rushworth.