New Dual-action Virus Effective in Treating Cancer
Food & Health  
news18

The team successfully tested the virus on samples of healthy human bone marrow and found it did not cause toxicity or inappropriate T cell activation.

 

Scientists have developed a genetically modified virus that can kill cancer cells as well as destroy their hiding places.
 
The novel dual-action virus, named as enadenotucirev, targets both cancer cells and fibroblasts -- healthy cells that are tricked into protecting the cancer from the immune system.
 
Currently, any therapy that kills the "tricked" fibroblast cells may also kill fibroblasts throughout the body -- for example, in the bone marrow and skin -- causing toxicity.
 
The new virus targets carcinomas, which are the most common type of cancer and start in cells in the skin or in tissues that line or cover internal organs, such as the pancreas, colon, lungs, breasts, ovaries and prostate.
 
"Even when most of the cancer cells in a carcinoma are killed, fibroblasts can protect the residual cancer cells and help them to recover and flourish. Until now, there has not been any way to kill both cancer cells and the fibroblasts protecting them at the same time, without harming the rest of the body," said Kerry Fisher, from Britain's University of Oxford.
 
"Our new technique to simultaneously target the fibroblasts while killing cancer cells with the virus could be an important step towards reducing immune system suppression within carcinomas and should kick-start the normal immune process," he added.
 
In the study, published in the journal Cancer Research, the team added genetic instructions into the virus that caused infected cancer cells to produce a protein called a bispecific T-cell engager.
 

 

The protein was then designed to bind to two types of cells and stick them together. In this case, one end was targeted to bind to fibroblasts. The other end specifically stuck to T cells -- a type of immune cell that is responsible for killing defective cells. This triggered the T cells to kill the attached fibroblasts.

 
The team successfully tested the virus on samples of healthy human bone marrow and found it did not cause toxicity or inappropriate T cell activation.
 
Enadenotucirev is already in clinical trials for treating carcinomas. It will be moving towards clinical trials as early as next year to find out if it is safe and effective in people with cancers.

 
 


 
 


 
More in Food & Health
How to Naturally Cure Skin Tags, Moles, Warts, Blackheads, and Age Spo...

People of all ages can be affected by skin issues and it is worth mentioning that the treatment can be quite problematic.

Recently posted . 21 views

HEALTH BENEFITS RELATED TO MOTORCYCLE RIDING

Chances are you’ve heard how dangerous it is to ride a motorcycle. How you are just risking your life being on your bike and you must have a death wish. For...

Recently posted . 29 views

A woman has a rare condition that prevents her from hearing male voice...

*After a night's sleep, a woman woke up unable to hear all men's voices including that of her boyfriend, The Daily Mail reported last wee...

Recently posted . 16 views

Fitness for your sake, not social media

These wellness trends are predicted to be the ones to watch out for this year.   The predictions have started pouring in with r...

Recently posted . 19 views

Here comes ‘stair snacking’ to improve heart health

Researchers have shown that a few minutes of stair climbing called the ‘stair snacking’ approach, at short intervals between work, can improve cardiovas...

Recently posted . 11 views

5 natural ways to keep acidity at bay during winters - Home remedies f...

Acid reflux, commonly known as acidity is a very common problem and can be treated with home remedies like buttermilk, cold milk, bananas, carrom seeds, tulsi leave...

Recently posted . 27 views

 
 
 

Prashnavali

Thought of the day

“Failure Will Never Overtake Me If My Determination To Succeed Is Strong Enough.”
Anonymous